Semaglutide: What It Is, FDA Status & Reconstitution Math
By James Li, Lead Editor · Updated · Reviewed
Quick answer
Semaglutide is the drug in Ozempic, Wegovy, and Rybelsus, which are FDA-approved pens or tablets that are already prepared, so a dry vial you mix is a different container and the milligrams printed on that vial are the ones to enter.
Once you have milligrams on the label and the milliliters of water you added, concentration is those milligrams divided by those milliliters, and a U-100 syringe reads that volume as 100 units per milliliter, so 10 units is 0.1 mL while one milligram is 1,000 micrograms.
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Waiting on Input
5 mg vial, 2 mL water, 250 mcg. Example only, not a dose.
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Illustrative arithmetic only, not a recommendation. The result for Semaglutide uses only the numbers you type.
What is Semaglutide?
Semaglutide is the drug in Ozempic, Wegovy, and Rybelsus.
Those brands are pens or tablets that are already prepared, while a dry vial you mix yourself is a different container, so enter the strength printed on the one you are measuring and do not read pen clicks as if you had reconstituted a powder.
What is the FDA status of Semaglutide?
Yes for Ozempic, Wegovy, and Rybelsus, while a compounded vial is not those brands.
The approval belongs to those branded products and the labels that come with them, so if your container is a compounded or research vial, read that container's own label, and the calculator will use whatever milligrams and milliliters you type without checking that they match a brand pen.
How is Semaglutide reconstituted?
Semaglutide brand pens are already liquid, so reconstitution does not apply to them.
It applies only when your container is a dry vial and the label says to add liquid, there is no single volume of water, and you enter the milligrams and the milliliters you added, knowing that more water lowers the amount in each syringe unit.
How do you convert Semaglutide mg to mcg and syringe units?
For Semaglutide, multiply milligrams by 1,000 to get micrograms.
That conversion does not produce a syringe mark, because units measure volume and you still divide the micrograms you want to measure by the micrograms in each milliliter.
How should Semaglutide be stored?
Storage for Semaglutide is on its own label, covering temperature, light, and how long it may be kept after mixing.
An unopened bottle and a mixed vial are not the same case, so if the label is missing ask the pharmacist or clinician who supplied it rather than borrowing a rule from a different product.
Where can I find primary sources on Semaglutide?
For the approval status of Semaglutide, start with Drugs@FDA and the product label on DailyMed.
Those are the places that say whether a named product is approved and what its label claims, and this page does not recap studies or change the calculator because of them.
Unit math
Illustrative arithmetic only. Not a dose. Barrel columns use a U-100 scale, 100 units per mL.
| Vial mg | Water mL | mg/mL | mcg/mL | mcg in 10 units |
|---|---|---|---|---|
| 10 | 4 | 2.5 | 2,500 | 250 |
| 5 | 1 | 5 | 5,000 | 500 |
| 10 | 2 | 5 | 5,000 | 500 |
| mL | 1 mL barrel (U-100 scale) | 0.5 mL barrel (U-100 scale) | 0.3 mL barrel (U-100 scale) |
|---|---|---|---|
| 0.05 | 5 | 5 | 5 |
| 0.1 | 10 | 10 | 10 |
| 0.25 | 25 | 25 | 25 |
| 0.5 | 50 | 50 | 50 (past barrel) |
| 1 | 100 | 100 (past barrel) | 100 (past barrel) |
FAQ
What is a compounded Semaglutide?
Compounded semaglutide means a pharmacy prepared it, rather than the brand pens or tablets Ozempic, Wegovy, and Rybelsus, which are already liquid or oral, so a compounded dry vial is a different container and only the numbers on the one you are measuring belong in the calculator.
Is Semaglutide FDA approved?
Yes for Ozempic, Wegovy, and Rybelsus, while a compounded vial is not those brands.
How do I use the Semaglutide calculator?
Type the milligrams on the vial, the milliliters of water you added, and the amount you want to measure, and the syringe mark updates in the calculator.
What is BAC water?
BAC water is bacteriostatic water, which is sterile water with a preservative used to dissolve a dry vial, and the volume you add is what sets the concentration.
How many units are in 1 ml on a U-100 syringe?
On a U-100 syringe, 1 mL is 100 units, 0.5 mL is 50 units, and 0.1 mL is 10 units, provided the barrel is long enough to hold that volume.
Sources
- Drugs@FDA, FDA
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